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Oxygen-Ozone (O2-O3) Therapy in Peripheral Arterial Disease (PAD): A Review Study

Authors Juchniewicz H, Lubkowska A

Received 24 March 2020

Accepted for publication 12 May 2020

Published 29 June 2020 Volume 2020:16 Pages 579—594

DOI https://doi.org/10.2147/TCRM.S255247

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


Hanna Juchniewicz, Anna Lubkowska

Department of Functional Diagnostics and Physical Medicine, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, Poland

Correspondence: Hanna Juchniewicz
Department of Functional Diagnostics and Physical Medicine, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Zolnierska 54, Szczecin 71-210, Poland
Tel +48 69 383 3737
Email h.a.juchniewicz@gmail.com

Abstract: The purpose of this study is to review the current knowledge of oxygen-ozone (O2-O3) therapy and its effects on peripheral artery disease (PAD) risk factors, symptoms, as well as on PAD patients’ quality of life. From the in vitro studies, it has been concluded that the oxygen-ozone therapy exerts a positive effect on the platelet aggregation, cell remodeling, cytoskeletal elements organization and mitochondria structure. In animal studies, it has been shown that the O2-O3 therapy is an effective method in hypertension, and it diminishes the hypoxia state of various tissues. Clinical studies have provided evidence on the oxygen-ozone therapy effectiveness in low perfusion syndromes and hyperglycemia, as well as conditions with oxidative stress and inflammation. The oxygen-ozone therapy promotes faster recovery and enhances healing processes. It appears to be an effective adjunctive therapy in preventing peripheral artery disease complications such as occurrence of cardiovascular event, amputation or other extreme surgical solutions. It has been concluded that the O2-O3 therapy improves the quality of life of PAD patients. The oxygen-ozone therapy appears to have no adverse events or side effects. Moreover, it is very cost-effective, as standard treatment costs can be reduced by 25%. Easy clinical protocols allow the implementation of oxygen-ozone therapy into the usual care of PAD patients. Finally, the O2-O3 therapy may be meaningful especially for older patients and patients who are not eligible for standard revascularization.

Keywords: amputation, diabetes mellitus, oxidative stress, wound healing

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