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Optic perineuritis: a retrospective case series

Authors Bergman O, Andersson T, Zetterberg M

Received 28 October 2016

Accepted for publication 4 April 2017

Published 8 June 2017 Volume 2017:10 Pages 181—188


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Olle Bergman,1 Tommy Andersson,1 Madeleine Zetterberg1,2

1Department of Ophthalmology, Sahlgrenska University Hospital, 2Department of Clinical Neuroscience/Ophthalmology, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden

Abstract: Optic perineuritis (OPN) is a rare inflammatory disorder involving the optic nerve sheath characterized by visual loss. OPN may be isolated and idiopathic or part of an underlying disorder. This case series aimed to help clinicians investigate and manage this disorder. Presentation, clinical findings, and treatment of OPN are discussed. After review of medical records at the ophthalmology clinic at Sahlgrenska University hospital in Gothenburg, Sweden, seven OPN patients (three men and four women) were identified and included in the present case series. These included idiopathic cases and patients with underlying disorders. Age at OPN diagnosis ranged from 26 to 64 years (mean age 55 years, median age 58 years). Five of the patients were treated with corticosteroids. This study suggests that a high-dose course of corticosteroids is important in the treatment of OPN in severely affected patients.

Keywords: glucocorticoids, prednisone, vision, corticosteroids, inflammation, idiopathic, magnetic resonance imaging

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