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Optic neuritis as an early sign of multiple sclerosis

Authors Kale N

Received 24 July 2015

Accepted for publication 23 March 2016

Published 26 October 2016 Volume 2016:8 Pages 195—202


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Margaret Wong-Riley

Nilufer Kale

Department of Neurology, Bakirkoy Prof Dr Mazhar Osman Training and Research Hospital, Istanbul, Turkey

Abstract: Optic neuritis (ON) is an acute inflammatory demyelinating disorder of the optic nerve. The general characteristics of isolated ON include unilateral, subacute, and painful visual loss without systemic or other neurological symptoms. The etiology for ON varies including demyelinating disorders or infections, inflammation, toxic reasons, and genetic disorders. In most cases the responsible etiology may not be known for ON and in this case, it is termed idiopathic ON. When a patient presents with an initial episode of ON, patients should undergo further tests. Assessing the patient with routine blood work, magnetic resonance imaging, cerebrospinal fluid tests, and visual evoked potentials provide further insight. In this review, we aimed to provide a review of ON as an initial symptom of multiple sclerosis and present clinical characteristics, therapy options, and recent literature.

Keywords: optic neuritis, multiple sclerosis, demyelination, corticosteroids, disease modifying treatments

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