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Onychomycosis treated with a dilute povidone–iodine/dimethyl sulfoxide preparation

Authors Capriotti K, Capriotti J

Received 19 June 2015

Accepted for publication 25 August 2015

Published 5 October 2015 Volume 2015:8 Pages 231—233

DOI https://doi.org/10.2147/IMCRJ.S90775

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Yang Liu

Peer reviewer comments 2

Editor who approved publication: Professor Ronald Prineas

Kara Capriotti,1,2,* Joseph A Capriotti1,3,*

1ALC Therapeutics, LLC, Springhouse, PA, 2Bryn Mawr Skin and Cancer Institute, Rosemont, PA, 3Plessen Ophthalmology Consultants, Christiansted, VI, USA

*These authors are related through marriage

Background: Povidone–iodine (PVP-I) 10% aqueous solution is a well-known, nontoxic, commonly used topical antiseptic with no reported incidence of fungal resistance. We have been using a low-dose formulation of 1% PVP-I (w/w) in a solution containing dimethyl sulfoxide (DMSO) in our clinical practice for a variety of indications. Presented here is our clinical experience with this novel formulation in a severe case of onychomycosis that was resistant to any other treatment.
Findings: A 49-year-old woman who had been suffering from severe onychomycosis for years presented after failing to find any remedy including over the counter (OTC), topical, and systemic oral prescribed therapies.
Conclusion: The topical povidone–iodine/DMSO system was very effective in this case at alleviating the signs and symptoms of onychomycosis. This novel combination warrants further investigation in randomized, controlled trials to further elucidate its clinical utility.

Keywords: onychomycosis, povidone–iodine, fungus, nail

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