Back to Journals » International Journal of Nanomedicine » Volume 6

Novel docetaxel-loaded nanoparticles based on PCL-Tween 80 copolymer for cancer treatment

Authors Ma Y, Zheng Y, Zeng X, Jiang L, Cheng H, Liu R, Huang L, Mei L

Published 1 November 2011 Volume 2011:6 Pages 2679—2688

DOI https://doi.org/10.2147/IJN.S25251

Review by Single-blind

Peer reviewer comments 2

Yuandong Ma1,2*, Yi Zheng1,2*, Xiaowei Zeng1-3*, Liqin Jiang4, Hongbo Chen1,2, Ranyi Liu5, Laiqiang Huang1,2, Lin Mei1,2
1School of Life Sciences, Tsinghua University, Beijing, 2Division of Life and Health Sciences, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, 3Materials and Environment Experimental Center, Department of Materials Science and Engineering, Qinhuangdao Branch, Northeastern University, Qinhuangdao, 4Insitute of Biomedical Engineering, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin, 5State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China
*These authors contributed equally to this work

Background: The formulation of docetaxel available for clinical use (Taxotere®) contains a high concentration of polysorbate 80 (Tween 80). After incorporation of Tween 80 into poly-ε-caprolactone (PCL)-Tween 80 copolymer, the relative amount of Tween 80 should be decreased and the advantages of PCL and Tween 80 should be combined.
Methods: A novel PCL-Tween 80 copolymer was synthesized from ε-caprolactone and Tween 80 in the presence of stannous octoate as a catalyst via ring opening polymerization. Two types of nanoparticle formulation were made from commercial PCL and a self-synthesized PCL-Tween 80 copolymer using a modified solvent extraction/evaporation method.
Results: The nanoparticles were found by field emission scanning electron microscopy to have a spherical shape and be 200 nm in diameter. The copolymers could encapsulate 10% of the drug in the nanoparticles and release 34.9% of the encapsulated drug over 28 days. PCL-Tween 80 nanoparticles could be internalized into the cells and had higher cellular uptake than the PCL nanoparticles. The drug-loaded PCL-Tween 80 nanoparticles showed better in vitro cytotoxicity towards C6 cancer cells than commercial Taxotere at the same drug concentration.
Conclusion: Nanoparticles using PCL-Tween 80 copolymer as drug delivery vehicles may have a promising outcome for cancer patients.

Keywords: cancer chemotherapy, docetaxel, nanoparticles, PCL-Tween 80

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Fabrication of genistein-loaded biodegradable TPGS-b-PCL nanoparticles for improved therapeutic effects in cervical cancer cells

Zhang H, Liu G, Zeng X, Wu Y, Yang C, Mei L, Wang Z, Huang L

International Journal of Nanomedicine 2015, 10:2461-2473

Published Date: 27 March 2015

Effects of Caryota mitis profilin-loaded PLGA nanoparticles in a murine model of allergic asthma

Xiao X, Zeng X, Zhang X, Ma L, Liu X, Yu H, Mei L, Liu Z

International Journal of Nanomedicine 2013, 8:4553-4562

Published Date: 25 November 2013

Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010