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Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients

Authors Głażewska EK, Niczyporuk M, Ławicki S, Szmitkowski M, Donejko M, Zajkowska M, Będkowska GE, Przylipiak A

Received 24 October 2016

Accepted for publication 10 March 2017

Published 27 April 2017 Volume 2017:13 Pages 575—582

DOI https://doi.org/10.2147/TCRM.S125595

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh

Edyta Katarzyna Głażewska,1 Marek Niczyporuk,1 Sławomir Ławicki,2 Maciej Szmitkowski,2 Magdalena Donejko,1 Monika Zajkowska,2 Grażyna Ewa Będkowska,3 Andrzej Przylipiak1

1Department of Esthetic Medicine, 2Department of Biochemical Diagnostics, 3Department of Haematological Diagnostics, Medical University, Bialystok, Poland

Background: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be associated with the pathogenesis and spread of psoriatic disease. This study was designed to investigate the plasma levels of MMP-3, MMP-9 and TIMP-3 in plaque psoriasis patients prior to and following a course of ultraviolet B narrowband treatment with respect to disease advancement. 
Methods:
Plasma samples of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were evaluated. Concentrations of MMP-3, MMP-9 and TIMP-3 were determined using enzyme-linked immunosorbent assay, while Psoriasis Area and Severity Index was used to define disease advancement. 
Results: Plasma levels of MMP-3, MMP-9 and TIMP-3 were significantly elevated in psoriasis patients compared to healthy individuals. A course of ultraviolet B narrowband treatment resulted in a significant decline in the studied metalloproteinases. Furthermore, the concentration of selected tissue inhibitors was negatively correlated with baseline Psoriasis Area and Severity Index score. 
Conclusion: Our research highlights the meaningful role of MMP-3, MMP-9 and TIMP-3 in psoriasis pathogenesis and clearance of disease symptoms. Furthermore, plasma levels of the analyzed metalloproteinases seem to be a valuable psoriasis biomarker.

Keywords: gelatinase B, stromelysin 1
 

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Other article by this author:

Therapy of psoriasis with narrowband ultraviolet-B light influences plasma concentrations of MMP-2 and TIMP-2 in patients

Głażewska EK, Niczyporuk M, Ławicki S, Szmitkowski M, Zajkowska M, Będkowska GE, Przylipiak A

Therapeutics and Clinical Risk Management 2016, 12:1579-1585

Published Date: 21 October 2016