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Nanoformulations of natural products for management of metabolic syndrome

Authors Taghipour YD, Hajialyani M, Naseri R, Hesari M, Mohammadi P, Stefanucci A, Mollica A, Farzaei MH, Abdollahi M

Received 30 April 2019

Accepted for publication 25 June 2019

Published 16 July 2019 Volume 2019:14 Pages 5303—5321

DOI https://doi.org/10.2147/IJN.S213831

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Thomas J. Webster


Yasamin Davatgaran Taghipour,1–3 Marziyeh Hajialyani,4 Rozita Naseri,5 Mahvash Hesari,6 Pantea Mohammadi,6 Azzurra Stefanucci,7 Adriano Mollica,7 Mohammad Hosein Farzaei,4,6 Mohammad Abdollahi8

1Department of Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; 2Phytopharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; 3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 4Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Internal Medicine Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran; 6Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; 7Department of Pharmacy, G. d’Annunzio University of Chieti-pescara, Chieti 66100, Italy; 8Toxicology and Diseases Group, the Institute of Pharmaceutical Sciences (TIPS) and Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Abstract: Metabolic syndrome is a common metabolic disorder which has become a public health challenge worldwide. There has been growing interest in medications including natural products as complementary or alternative choices for common chemical therapeutics regarding their limited side effects and ease of access. Nanosizing these compounds may help to increase their solubility, bioavailability, and promisingly enhance their efficacy. This study, for the first time, provides a comprehensive overview of the application of natural-products-based nanoformulations in the management of metabolic syndrome. Different phytochemicals including curcumin, berberine, Capsicum oleoresin, naringenin, emodin, gymnemic acid, resveratrol, quercetin, scutellarin, stevioside, silybin, baicalin, and others have been nanosized hitherto, and their nanosizing method and effect in treatment and alleviating metabolic syndrome have been reviewed and discussed in this study. It has been discovered that there are several pathways or molecular targets relevant to metabolic disorders which are affected by these compounds. Various natural-based nanoformulations have shown promising effect in treatment of metabolic syndrome, and therefore can be considered as future candidates instead of or in conjunction with pharmaceutical drugs if they pass clinical trials successfully.

Keywords: nanoformulation, natural products, metabolic syndrome, diabetes

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