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Metered Cryospray™: a novel uniform, controlled, and consistent in vivo application of liquid nitrogen cryogenic spray

Authors Mulcahey TI, Coad JE, Fan WL, Grasso DJ, Hanley BM, Hawkes HV, McDermott SA, O'Connor JP, Sheets EE, Vadala CJ

Received 7 October 2016

Accepted for publication 15 December 2016

Published 17 February 2017 Volume 2017:10 Pages 29—41

DOI https://doi.org/10.2147/MDER.S124098

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Video abstract presented by Thomas I Mulcahey

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Thomas I Mulcahey,1 James E Coad,2 Wei Li Fan,1 Daniel J Grasso,1 Brian M Hanley,1 Heather V Hawkes,1 Sean A McDermott,1 John P O’Connor,1 Ellen E Sheets,1 Charles J Vadala1

1CSA Medical Inc., Lexington, MA, 2Pathology Laboratory for Translational Medicine, West Virginia University, Morgantown, WV, USA

Abstract: In this article, a novel cryotherapy approach using a uniform, controlled, and consistent in vivo application of liquid nitrogen (LN2) spray as a Metered Cryospray™ (MCS) process is described. Although MCS may be used for many potential clinical applications, this paper focuses on the development that led to the controlled and consistent delivery of radial LN2 cryogen spray in order to generate a uniform circumferential effect and how the amount of MCS can be adapted to specifically ablate targeted diseases within a patient’s lumen such as an airway or esophagus.

Keywords: Metered Cryospray™, cryoablation, rejuvenative healing, LN2 spray cryotherapy

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