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Maintaining remission in ulcerative colitis – role of once daily extended-release mesalamine

Authors Oliveira, Cohen R

Published 27 February 2011 Volume 2011:5 Pages 111—116

DOI https://doi.org/10.2147/DDDT.S5392

Review by Single-blind

Peer reviewer comments 4


Lilliana Oliveira, Russell D Cohen
The Department of Medicine, Section of Gastroenterology, University of Chicago Medical Center, Chicago, IL, USA

Abstract: The aminosalicylates (5-ASA; also referred to as mesalamine-based agents) are considered as first-line in the maintenance of remission of mild to moderate ulcerative colitis (UC). Traditionally these agents have required a large pill burden and multiple daily dosing regimens which may account for the low adherence rates, especially in patients in remission. Extended-release mesalamine is the first once daily mesalamine product approved by the Food and Drug Administration for the maintenance of UC remission. This review will examine the pharmacokinetics, dosing, efficacy, and safety data of extended-release mesalamine, and discuss the potential role of improving medication compliance and decreasing costs in UC maintenance.

Keywords: ulcerative colitis, 5-ASA, mesalamine, adherence, compliance, quality of life, costs

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