Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients
Received 16 March 2018
Accepted for publication 17 May 2018
Published 24 August 2018 Volume 2018:13 Pages 1475—1483
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 3
Editor who approved publication: Dr Wu
Xue-qiang Guan,1 Yang-jing Xue,2 Jie Wang,2 Jun Ma,2 Yue-chun Li,2 Cheng Zheng,2 Sai-zhu Wu1
1Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
Background: Accelerated atherosclerosis is considered to be the linking factor between low bone mineral density (BMD) and increased cardiovascular events and mortality, while some coronary angiographic studies do not support this point. In this study, we attempt to provide a distinct comprehensive view of the relationship between BMD and the angiographically determined coronary atherosclerotic burden.
Methods: A total of 459 consecutive patients with stable chest pain suspected of coronary artery disease (CAD) underwent both dual-energy X-ray absorptiometry scan and selective coronary angiography. The association between BMD and global coronary atherosclerotic plaque burden as represented by the multivessel involvement and the modified Gensini score was analyzed.
Results: Multivariable analysis revealed that the low BMD at femoral neck and total hip was an independent correlate of multivessel CAD. The T-scores measured at femoral neck and total hip were both negatively and independently associated to the modified Gensini score. These inversely correlated relationships between BMD and CAD were not observed at lumbar spine 1–4.
Conclusion: This cross-sectional study elucidated an inverse relationship between hip BMD and the modified Gensini score, and low hip BMD values (T-scores) were significantly and independently associated with increased risk of multivessel coronary disease in patients hospitalized for stable chest pain.
Keywords: coronary artery disease, bone mineral density, global coronary atherosclerotic plaque burden, modified Gensini score
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