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Long-term effects of antihypertensive medications on bone mineral density in men older than 55 years

Authors Ağaçayak K, Güven S, Koparal M, Güneş N, Atalay Y, Atılgan S

Received 14 January 2014

Accepted for publication 13 February 2014

Published 27 March 2014 Volume 2014:9 Pages 509—513

DOI https://doi.org/10.2147/CIA.S60669

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Kamil Serkan Ağaçayak,1 Sedat Güven,2 Mahmut Koparal,1 Nedim Güneş,1 Yusuf Atalay,3 Serhat Atilgan1

1Department of Oral and Maxillofacial Surgery, 2Department of Prosthodontics, School of Dentistry, University of Dicle, Diyarbakir, Turkey; 3Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Afyon Kocatepe, Afyon, Turkey

Introduction: In this study, we investigated the effects of long-term antihypertensive treatment with calcium channel blockers or beta blockers on the bone mineral density of maxilla, as determined by cone-beam computed tomography (CBCT).
Material and methods: This retrospective study was conducted on CBCT images of men older than 55 years who had received different dental indications. Data were grouped into three categories according to the antihypertensive medication history of the patients: group A included patients who had been taking beta-blocker treatment for more than 5 years, group B included patients who had been taking calcium channel blocker treatment for more than 5 years, and the control group included patients who had never used any hypertensive medications before.
Results: Statistically significant differences were observed between the beta blocker and calcium channel blocker groups.
Conclusion: In hypertension treatment, beta blockers may be preferred to calcium channel blockers in patients at high risk for osteoporosis and bone resorption.

Keywords: bone mineral density, CBCT, beta blockers, calcium channel blockers

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