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Letter

Rhegmatogenous retinal detachments in pediatric vitreoretinopathies in Saudi Arabia

       

Authors Khan A

Received 15 February 2016

Accepted for publication 16 February 2016

Published 15 April 2016 Volume 2016:10 Pages 663—664

DOI https://doi.org/10.2147/OPTH.S106461

Checked for plagiarism Yes

Editor who approved publication: Dr Scott Fraser

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Arif O Khan

Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

 

I congratulate the authors on their retrospective study of rhegmatogenous retinal detachment in patients (mostly children) diagnosed with Stickler syndrome in Saudi Arabia1. However, I would like to point out that this work would more appropriately be considered a retrospective study of vitreoretinopathies in general rather than of Stickler syndrome specifically because a percentage of cases were likely recessive vitreoretinopathies. In my experience, children in Saudi Arabia with pediatric retinal detachment and high myopia are often labeled as having Stickler syndrome while in fact recessive vitreoretinopathies such as Knobloch syndrome2 or LRPAP1-related high myopia3 comprise a significant percentage of cases. 

 

View original article by Alshahrani et al.

Dear editor

I congratulate the authors on their retrospective study of rhegmatogenous retinal detachment in patients (mostly children) diagnosed with Stickler syndrome in Saudi Arabia.1 However, I would like to point out that this work would more appropriately be considered a retrospective study of vitreoretinopathies in general rather than of Stickler syndrome specifically because a percentage of cases were likely recessive vitreoretinopathies. In my experience, children in Saudi Arabia with pediatric retinal detachment and high myopia are often labeled as having Stickler syndrome while in fact recessive vitreoretinopathies such as Knobloch syndrome2 or LRPAP1-related high myopia3 comprise a significant percentage of cases. In addition, even when a child from Saudi Arabia truly has Stickler syndrome, it is typically a special recessive form of vitreoretinopathy from a biallelic collagen gene mutation rather than the classic autosomal dominant Stickler syndrome that is recognized worldwide and is due to a heterozygous COL2A1 mutation (unpublished data, 2004–2015).

Disclosure

The author reports no conflicts of interest or financial disclosures in this communication.

References

1.

Alshahrani ST, Ghazi NG, Al-Rashaed S. Rhegmatogenous retinal detachments associated to Stickler syndrome in a tertiary eye care center in Saudi Arabia. Clin Ophthalmol. 2015;10:1–6. doi:10.2147/OPTH.S91444. eCollection 2016. PubMed PMID: 26730175.

2.

Khan AO, Aldahmesh MA, Mohamed JY, Al-Mesfer S, Alkuraya FS. The distinct ophthalmic phenotype of Knobloch syndrome in children. Br J Ophthalmol. 2012;96(6):890–895. doi:10.1136/bjophthalmol-2011-301396.

3.

Khan AO, Aldahmesh MA, Alkuraya FS. Clinical characterization of LRPAP1-related pediatric high myopia. Ophthalmology. 2016;123(2):434–435.

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