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Issues with Intravitreal Administration of Anti-VEGF Drugs

Authors Schargus M, Frings A

Received 2 February 2020

Accepted for publication 10 March 2020

Published 23 March 2020 Volume 2020:14 Pages 897—904

DOI https://doi.org/10.2147/OPTH.S207978

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Marc Schargus,1,2 Andreas Frings1,3

1Department of Ophthalmology, Heinrich Heine University, Duesseldorf, Germany; 2Department of Ophthalmology, Asklepios Hospital Nord-Heidberg, Hamburg, Germany; 3Augenarztpraxis Dr. Frings, Nuremberg, Germany

Correspondence: Marc Schargus
Department of Ophthalmology, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany
Tel +49-177-6272724
Email marc.schargus@gmx.de

Purpose: To provide an update of summary of risk factors and side effects of long-term use and contamination of intravitreal anti-VEGF injections.
Methods: We reviewed relevant publications of the topic of contamination of anti-VEGF injections and long-term side effects due to this reason.
Results: Due to the long-term use of anti-VEGF drugs and the higher number of injections worldwide, various studies have shown side effects in recent years, ranging from increased intraocular pressure to visual disturbing silicone oil vesicles in the vitreous cavity. Several studies have demonstrated that both the drug and the processing, storage, environmental factors and the material and design of the syringes have a decisive influence on these side effects.
Conclusion: The risks of deposits from syringes in the eye can be significantly reduced by various optimizations in transport, storage and syringe and cannula selection.

Keywords: contamination, intraocular pressure, protein particles, silicone oil, syringes, macular diseases


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