Involvement of the nuclear structural proteins in aging-related responses of human skin to the environmental stress

Ewa Markiewicz, Olusola Clement Idowu

Hexis Lab, Science Central, The Core, Newcastle upon Tyne, UK

Abstract: Human skin is a stratified endocrine organ with primary roles in protection against detrimental biochemical and biophysical factors in the environment. Environmental stress causes gradual accumulation of the macromolecular damage and clinical manifestations consistent with chronic inflammatory conditions and premature aging of the skin. Structural proteins of cell nucleus, the nuclear lamins and lamina-associated proteins, play an important role in the regulation of a number of signal transduction pathways associated with stress. The nuclear lamina proteins have been implicated in a number of degenerative disorders with frequent clinical manifestations of the skin conditions related to premature aging. Analysis of the molecular signatures in response of the skin to a range of damaging factors not only points at the likely involvement of the nuclear lamina in transmission of the signals between the environment and cell nucleus but also defines skin’s sensitivity to stress, and therefore the capacities to counteract external damage in aging.

Keywords: genotoxic, nuclear lamina, progeroid syndrome, fibroblast