Investigating the therapeutic potential of a probiotic in a clinical population with chronic hand dermatitis
Authors Gulliver WP, Hutton AS, Ship N
Received 7 February 2018
Accepted for publication 6 March 2018
Published 30 May 2018 Volume 2018:11 Pages 265—271
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Ms Justinn Cochran
Peer reviewer comments 3
Editor who approved publication: Dr Jeffrey Weinberg
Wayne P Gulliver,1 Andrew S Hutton,1 Noam Ship2
1NewLab Life Sciences Inc., St. John’s, NL, Canada; 2Research and Development, Bio-K Plus International Inc., Laval, QC, Canada
Background: Hand dermatitis or hand eczema (HD) is one of the most common dermatologic conditions. Lesions, scaling, pruritus and pain are chronic and relapsing. Improved HD has been reported with the probiotic composed of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 (Bio-K+).
Purpose: Investigation of the therapeutic potential of this probiotic as the sole systemic treatment for adults with nonacute HD.
Subjects and methods: A single-center study documented clinical ratings and patient-reported outcomes in adults with chronic HD. The probiotic was taken orally for 12 weeks, adjunctive to standard topical treatments and preventative measures.
Results: Most of the 30 subjects with mild to severe HD were compliant with the probiotic. Around 22 of the 30 subjects were able to complete the study, and of these subjects, an improvement was noted in 19. One required systemic therapy, and one subject was not able to tolerate the probiotic and therefore discontinued the study. 23% of the subjects achieved clear or almost clear hands by the end of 12 weeks. Pruritus, which was a common complaint at baseline, was improved with 59% of symptomatic patients within 2 weeks.
Conclusion: It is feasible and safe to administer Bio-K+ for HD. Clinicians saw an improvement in most subjects’ hands, and cases of significant improvement in dermatitis were documented. Pruritus was the most rapidly relieved symptom, as reported by patients.
Keywords: hand dermatitis, eczema, CL1285, Lactobacillus, pruritus, Bio-K+
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]