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Influence of sex on outcomes after percutaneous coronary intervention in patients over 75 years of age with coronary heart disease

Authors Liu Y, Hu X, Xue Q, Zhao Y, Wang Y, Gao L

Received 18 February 2014

Accepted for publication 30 May 2014

Published 23 October 2014 Volume 2014:9 Pages 1831—1837

DOI https://doi.org/10.2147/CIA.S62643

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Yuqi Liu,* Xin Hu,* Qiao Xue, Yusheng Zhao, Yu Wang, Lei Gao

Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China

*These authors contributed equally to this work

Background: This study aimed to investigate whether there were sex differences in in-hospital and long-term outcomes for elderly patients over 75 years of age undergoing percutaneous coronary intervention for coronary heart disease.
Methods: Consecutive patients aged ≥75 years who underwent percutaneous coronary intervention at a single center in the People’s Republic of China from January 2005 to December 2010 were included in this cohort study. Clinical characteristics and in-hospital and long-term outcomes were compared between men and women.
Results: A total of 465 patients (34.8% women, mean age 78.5±3.2 years) were recruited. Men had a higher prevalence of ST elevation myocardial infarction but were less likely to have heart failure than women (P<0.05). Similar rates of successful in-hospital procedures and deaths were observed in men and women. After a mean follow-up of 3 years, no significant differences were observed between men and women in mortality (12.5% versus 8.0%, P=0.151), myocardial infarction (1.4% versus 2.7%, P=0.368), target vessel revascularization (6.1% versus 4.7%, P=0.540), or cerebral vascular disease (7.9% versus 6.0%, P=0.472). Cox proportional hazards analysis revealed that sex was not independently associated with either in-hospital mortality or long-term mortality.
Conclusion: In elderly patients over 75 years of age, sex influences the prognosis after percutaneous coronary intervention for coronary heart disease.

Keywords: percutaneous coronary intervention, elderly, sex

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