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Indocyanine Green-Parthenolide Thermosensitive Liposome Combination Treatment for Triple-Negative Breast Cancer

Authors Jin X, Lu X, Zhang Z, Lv H

Received 8 January 2020

Accepted for publication 14 April 2020

Published 5 May 2020 Volume 2020:15 Pages 3193—3206

DOI https://doi.org/10.2147/IJN.S245289

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Mian Wang


Xin Jin,1,2 Xinyue Lu,3 Zhenhai Zhang,4 Huixia Lv3

1Department of Hospital Pharmacy, Suqian First Hospital, Suqian 223800, People’s Republic of China; 2Department of Pharmaceutics, Suqian Clinical College of Xuzhou Medical University, Suqian 223800, People’s Republic of China; 3Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, People’s Republic of China; 4Jiangsu Province Hospital on Integration of Chinese and Western Medicine Affiliated with Nanjing University of Chinese Medicine, Nanjing 210000, People’s Republic of China

Correspondence: Zhenhai Zhang; Huixia Lv Tel +8618913823932
; +8613912965842
Email david23932@163.com; lvhuixia@163.com

Background: Certain patients with triple-negative breast cancer cannot tolerate the serious adverse effects of cytotoxic chemotherapy agents, which significantly affect the disease prognosis.
Purpose: Research into the combined use of photosensitizers and non-cytotoxic antineoplastic drugs for the safe treatment of triple-negative breast cancer is vital.
Methods: In this study, the photosensitizer indocyanine green and the natural drug parthenolide were co-loaded into thermosensitive liposomes. Under a near-infrared irradiation, indocyanine green reached excitation levels, releasing heat, and the liposome underwent a phase transition, releasing the drug were researched.
Results: Thus, indocyanine green and parthenolide exert synergistic antineoplastic effects. In the nude mice xenograft MDA-MB-231 tumor model, the tumor inhibition rate of indocyanine green-parthenolide thermosensitive liposomes was approximately 2.08-fold than that of paclitaxel and demonstrated a good initial safety evaluation.
Conclusion: Photosensitizers and non-cytotoxic antineoplastic agents in combination with nanoscale carriers should be further investigated for the treatment of tumors.

Keywords: indocyanine green, parthenolide, thermosensitive liposomes, triple-negative breast cancer, chemo-photothermal synergetic therapy

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