In vivo validation of the multicomponent powder (Vitachelox®) against the deposition of polluting ions
Authors Giacomelli L, Togni S, Meneghin M, Eggenhöffner R, Maramaldi G
Received 7 November 2017
Accepted for publication 17 January 2018
Published 8 March 2018 Volume 2018:11 Pages 109—113
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Ms Justinn Cochran
Peer reviewer comments 2
Editor who approved publication: Dr Jeffrey Weinberg
Luca Giacomelli,1 Stefano Togni,2 Martino Meneghin,2 Roberto Eggenhöffner,1 Giada Maramaldi2
1Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genoa, Italy; 2Indena S.p.A, Milan, Italy
Purpose: The purpose of this in vivo study is to evaluate the acute clinical application of a multicomponent powder (Vitachelox®), including three naturally occurring standardized extracts rich in polyphenols (grape seed extract, green tea extract, oak wood/bark extract), on healthy volunteers by measuring prevention of any metal deposition within the stratum corneum (SC) following a 6-h exposure period in a polluted environment.
Patients and methods: In this in vivo study, we evaluated the skin protective activity of the multicomponent powder formulated in a base emulsion compared to a relevant placebo cream. Using the tape stripping method, SC samples of face skin obtained from 30 healthy volunteers were compared following a 6-h exposure in a polluted area.
Results: No statistically significant variations on the amount of heavy metals were found in the samples of SC cells obtained from the hemi-faces treated with the multicomponent powder, with respect to baseline. On the contrary, a significantly higher concentration of heavy metals was found in the cells samples obtained from the hemi-faces treated with the placebo cream. In particular, an increased concentration of heavy metals superior to 100% were found for iron and zinc (+130.2% and +142.6%, respectively; p<0.001).
Conclusion: This in vivo study validates and extends previous in vitro findings, indicating that the multicomponent powder allows the prevention of any metal deposition within the SC following exposure in a polluted environment. Our results suggest that the test product could play an effective role in counteracting skin damages induced by air pollution.
Keywords: air pollution, heavy metals, oxidative stress, polyphenols, green tea extract, oak wood extract, grape seed extract, antipollution, stratum corneum
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