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Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies

Authors Zhang HZ, Sun Y, Tian A, Xue XX, Wang L, Alquhali A, Bai XZ

Received 18 August 2013

Accepted for publication 26 September 2013

Published 8 November 2013 Volume 2013:8(1) Pages 4379—4389

DOI https://doi.org/10.2147/IJN.S53221

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Hangzhou Zhang,1 Yu Sun,1 Ang Tian,2 Xiang Xin Xue,2 Lin Wang,1 Ali Alquhali,1 Xizhuang Bai1

1Department of Sports Medicine and Joint Surgery, First Affiliated Hospital of China Medical University, 2School of Materials and Metallurgy, Northeastern University, Shenyang, People's Republic of China

Abstract: The goal for current orthopedic implant research is to design implants that have not only good biocompatibility but also antibacterial properties. TiO2 nanotubes (NTs) were fabricated on the titanium surface through electrochemical anodization, which added new properties, such as enhanced biocompatibility and potential utility as drug nanoreservoirs. The aim of the present study was to investigate the antibacterial properties and biocompatibility of NTs loaded with vancomycin (NT-V), both in vitro and in vivo. Staphylococcus aureus was used to study the antibacterial properties of the NT-V. There were three study groups: the commercially pure titanium (Cp-Ti) group, the NT group (nonloaded vancomycin), and the NT-V group. We compared NT-V biocompatibility and antibacterial efficacy with those of the NT and Cp-Ti groups. Compared with Cp-Ti, NT-V showed good antibacterial effect both in vitro and in vivo. Although the NTs reduced the surface bacterial adhesion in vitro, implant infection still developed in in vivo studies. Furthermore, the results also revealed that both NTs and NT-V showed good biocompatibility. Therefore, the NTs loaded with antibiotic might be potentially used for future orthopedic implants.

Keywords: TiO2 nanotubes, biocompatibility, antibacterial properties, osteoblasts, vancomycin

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