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Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: clinical perspectives

Authors Bajgai P, Katoch D, Dogra MR, Singh R

Received 13 August 2017

Accepted for publication 6 September 2017

Published 6 October 2017 Volume 2017:11 Pages 1805—1817

DOI https://doi.org/10.2147/OPTH.S128506

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Priya Bajgai, Deeksha Katoch, Mangat Ram Dogra, Ramandeep Singh

Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Abstract: Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome typically affects young, healthy individuals. Despite the dramatic fundus appearance seen in this syndrome, these patients are usually asymptomatic. The syndrome includes peculiar vascular abnormalities in the form of multiple aneurysmal dilatations seen along retinal arterioles and optic nerve-head arterioles, which are best appreciated on fluorescein angiography. Neuroretinitis and retinal vasculitis are seen in all patients, and manifested by staining of the optic nerve head and diffuse leakage from vessels, mainly arterioles, on fluorescein angiography. The devastating vision-threatening outcomes of this syndrome include exudative retinopathy and extensive peripheral retinal nonperfusion areas, which can eventually lead to neovascularization. This review summarizes current knowledge on the variable clinical aspects of this disease, highlighting diagnostic and treatment strategies.

Keywords:
IRVAN, aneurysmal dilatation, neuroretinitis, panretinal photocoagulation

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