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Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Authors Vieira DB, Gamarra LF

Received 14 July 2016

Accepted for publication 7 September 2016

Published 18 October 2016 Volume 2016:11 Pages 5381—5414

DOI https://doi.org/10.2147/IJN.S117210

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Thomas Webster


Débora B Vieira,1 Lionel F Gamarra1,2

1Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil

Abstract: This review summarizes articles that have been reported in literature on liposome-based strategies for effective drug delivery across the blood–brain barrier. Due to their unique physicochemical characteristics, liposomes have been widely investigated for their application in drug delivery and in vivo bioimaging for the treatment and/or diagnosis of neurological diseases, such as Alzheimer’s, Parkinson’s, stroke, and glioma. Several strategies have been used to deliver drug and/or imaging agents to the brain. Covalent ligation of such macromolecules as peptides, antibodies, and RNA aptamers is an effective method for receptor-targeting liposomes, which allows their blood–brain barrier penetration and/or the delivery of their therapeutic molecule specifically to the disease site. Additionally, methods have been employed for the development of liposomes that can respond to external stimuli. It can be concluded that the development of liposomes for brain delivery is still in its infancy, although these systems have the potential to revolutionize the ways in which medicine is administered.

Keywords: Alzheimer, Parkinson, stroke, cerebral ischemia, glioma, liposomes, blood–brain barrier

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