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Functional Relevancies of Trans-Differentiation in the Juxtaglomerular Apparatus of Rat Kidney

Authors Razga Z

Received 17 January 2020

Accepted for publication 9 May 2020

Published 12 June 2020 Volume 2020:13 Pages 147—156

DOI https://doi.org/10.2147/IJNRD.S246476

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Pravin Singhal


Zsolt Razga

Department of Pathology, University of Szeged, Szeged, Hungary

Correspondence: Zsolt Razga
Department of Pathology, University of Szeged, Állomás U. 2, Szeged H 6725, Hungary
Tel/ Fax +36 62 545162
Email razga.zsolt@med.u-szeged.hu

Abstract: Glomerular filtration rate is controlled by the contractile effect of angiotensin II on afferent and efferent arterioles. The renin positivity of the afferent arterioles depends on tubuloglomerular feedback via the macula densa (MD) and short loop feedback via the afferent arteriolar endothelia. The renin-producing cells are trans-differentiated from smooth muscle cells (SMCs) of mainly the afferent arterioles, the MD cells are trans-differentiated from the neighboring tubular cells, and the high-permeability endothelial cells are trans-differentiated from normal permeability endothelial cells facing the renin-negative part of the afferent arterioles. All of the trans-differentiations depend on the activity of the renin-angiotensin system (RAS). The distribution of AT1 receptors for angiotensin II expresses the contractile effects of angiotensin II on renin-negative SMCs and the negative effect on trans-differentiation of renin-positive SMCs and MD cells. The purpose of this review is to summarize the stereological data of molecules like angiotensin II AT1 receptors, L-type calcium channels, and renin receptors in the juxtaglomerular apparatus of normal and STZ-induced diabetic rat kidneys, thus showing their functional relevancies on trans-differentiation among the juxtaglomerular apparatus’ elements.

Keywords: angiotensin II, renin, trans-differentiation, kidney, arteriole, afferent arteriole, efferent arteriole, tubuloglomerular feedback, macula densa

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