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Fuchs endothelial corneal dystrophy: current perspectives

Authors Vedana G, Villarreal Jr. G, Jun A

Received 30 October 2015

Accepted for publication 14 January 2016

Published 18 February 2016 Volume 2016:10 Pages 321—330

DOI https://doi.org/10.2147/OPTH.S83467

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ahmed Abd Elhamid Hosni

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Gustavo Vedana, Guadalupe Villarreal Jr, Albert S Jun

Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA

Abstract: Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet’s membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress contribute to disease progression. The genetic basis of FECD includes numerous genes and chromosomal loci, although alterations in the transcription factor 4 gene are associated with the majority of cases. Definitive treatment of FECD is corneal transplantation. In this paper, we highlight advances that have been made in understanding FECD’s clinical features, pathophysiology, and genetics. We also discuss recent advances in endothelial keratoplasty and potential future treatments.

Keywords
: Fuchs endothelial corneal dystrophy, corneal endothelial cell, corneal transplantation, Descemet’s stripping automated endothelial keratoplasty, Descemet’s membrane endothelial keratoplasty, endothelial keratoplasty

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