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Fractional exhaled nitric oxide-measuring devices: technology update

Authors Maniscalco M, Vitale C, Vatrella A, Molino A, Bianco A, Mazzarella G

Received 29 February 2016

Accepted for publication 9 April 2016

Published 23 June 2016 Volume 2016:9 Pages 151—160

DOI https://doi.org/10.2147/MDER.S91201

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Mauro Maniscalco,1 Carolina Vitale,2 Alessandro Vatrella,2 Antonio Molino,3 Andrea Bianco,4 Gennaro Mazzarella4

1Unit of Respiratory Diseases, Hospital “S Maria della Pietà” of Casoria, Naples, 2Unit of Respiratory Medicine, Department of Medicine and Surgery, University of Salerno, Salerno, 3Department of Respiratory Medicine, University Federico II, 4Department of Cardiothoracic and Respiratory Sciences, Second, University of Naples, Naples, Italy


Abstract: The measurement of exhaled nitric oxide (NO) has been employed in the diagnosis of specific types of airway inflammation, guiding treatment monitoring by predicting and assessing response to anti-inflammatory therapy and monitoring for compliance and detecting relapse. Various techniques are currently used to analyze exhaled NO concentrations under a range of conditions for both health and disease. These include chemiluminescence and electrochemical sensor devices. The cost effectiveness and ability to achieve adequate flexibility in sensitivity and selectivity of NO measurement for these methods are evaluated alongside the potential for use of laser-based technology. This review explores the technologies involved in the measurement of exhaled NO.

Keywords: asthma, inflammation, nasal nitric oxide

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