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Factors affecting medication adherence in community-managed patients with hypertension based on the principal component analysis: evidence from Xinjiang, China

Authors Zhang YJ, Li XJ, Mao L, Zhang M, Li K, Zheng YX, Cui WF, Yin HP, He YL, Jing MX

Received 1 December 2017

Accepted for publication 24 February 2018

Published 11 May 2018 Volume 2018:12 Pages 803—812

DOI https://doi.org/10.2147/PPA.S158662

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Doris YP Leung

Peer reviewer comments 2

Editor who approved publication: Dr Naifeng Liu


Yuji Zhang,* Xiaoju Li,* Lu Mao, Mei Zhang, Ke Li, Yinxia Zheng, Wangfei Cui, Hongpo Yin, Yanli He, Mingxia Jing

Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang, China

*These authors contributed equally to this work

Purpose: The analysis of factors affecting the nonadherence to antihypertensive medications is important in the control of blood pressure among patients with hypertension. The purpose of this study was to assess the relationship between factors and medication adherence in Xinjiang community-managed patients with hypertension based on the principal component analysis.
Patients and methods: A total of 1,916 community-managed patients with hypertension, selected randomly through a multi-stage sampling, participated in the survey. Self-designed questionnaires were used to classify the participants as either adherent or nonadherent to their medication regimen. A principal component analysis was used in order to eliminate the correlation between factors. Factors related to nonadherence were analyzed by using a χ2-test and a binary logistic regression model.
Results: This study extracted nine common factors, with a cumulative variance contribution rate of 63.6%. Further analysis revealed that the following variables were significantly related to nonadherence: severity of disease, community management, diabetes, and taking traditional medications.
Conclusion: Community management plays an important role in improving the patients’ medication-taking behavior. Regular medication regimen instruction and better community management services through community-level have the potential to reduce nonadherence. Mild hypertensive patients should be monitored by community health care providers.

Keywords: hypertension, medication adherence, factors, principal component analysis, community management, China

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