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Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

Authors Zhang Y, Bi J, Huang J, Tang Y, Du S, Li P

Received 25 May 2020

Accepted for publication 24 August 2020

Published 22 September 2020 Volume 2020:15 Pages 6917—6934

DOI https://doi.org/10.2147/IJN.S264498

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Yi Zhang, Jiayao Bi, Jiayi Huang, Yanan Tang, Shouying Du, Pengyue Li

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China

Correspondence: Pengyue Li Email lipengyuetougao@126.com

Abstract: Exosomes are nano-sized small extracellular vesicles secreted by cells, carrying nucleic acids, proteins, lipids and other bioactive substances to play a role in the body’s physiological and pathological processes. Compared to synthetic carriers such as liposomes and nanoparticles, the endogeneity and heterogeneity of exosomes give them extensive and unique advantages in the field of disease diagnosis and treatment. However, the storage stability, low yield, low purity, and weak targeting of exosomes limit its clinical application. For this reason, further exploration is needed to optimize the above problems and facilitate future functional studies of exosomes. In this paper, the origin, classification, preparation and characterization, storage stability and applications of exosome delivery system are summarized and discussed by searching a large number of literatures.

Keywords: exosomes, extraction and purification, storage stability, biomarkers, targeted drug delivery, surface modification

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