Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus
Received 14 October 2019
Accepted for publication 17 December 2019
Published 28 February 2020 Volume 2020:14 Pages 589—595
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Iman M Eissa, Ghada A Nassar, Shaimaa A Arfeen, Ahmed A Dahab
Department of Ophthalmology, Cairo University, Giza, Egypt
Correspondence: Ahmed A Dahab
Cairo University, 27 Madinat Al-Mabouthin, Giza, Egypt
Purpose: To evaluate the corneal pachymetric and topographic parameters of systemic Lupus Erythematosus (SLE) patients using Dual Scheimpflug Imaging.
Methods: This observational cross-sectional controlled study included the right eye of 30 SLE patients and 30 age-matched controls. Corneal measurements were acquired by dual Scheimpflug imaging including anterior and posterior corneal curvatures, central, mid-peripheral corneal thickness (measured at the 5 mm zone) and peripheral pachymetry (measured at the 7 mm zone). SLE disease activity index (SLEDAI) was calculated and correlated with corneal pachymetry.
Results: SLE patients had significantly thicker corneal periphery than controls. Mean central corneal pachymetry was 530.4± 27.3 microns (SD) in SLE and 547.5± 31.5 microns (SD) in control group, p = 0.032. The corneal periphery – except superiorly – was significantly thicker in SLE patients than controls (p ˂0.001). Nasal peripheral corneal thickness positively correlated with disease activity index SLEDAI (p=0.03).
Conclusion: SLE patients present with thicker corneal periphery than controls characteristically sparing the superior quadrant. Possible corneal photosensitivity leading to peripheral immune complex deposition as well as flatter posterior corneal surface at the periphery are proposed explanations for these findings.
Keywords: cornea, corneal pachymetry, corneal topography, SLEDAI score, systemic lupus erythematosus
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