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Evaluating the role of small particle hyaluronic acid fillers using micro-droplet technique in the face, neck and hands: a retrospective chart review

Authors Nikolis A, Enright KM

Received 26 May 2018

Accepted for publication 12 September 2018

Published 10 October 2018 Volume 2018:11 Pages 467—475

DOI https://doi.org/10.2147/CCID.S175408

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 4

Editor who approved publication: Dr Jeffrey Weinberg


Andreas Nikolis,1–4 Kaitlyn M Enright1,3–5

1Victoria Park Medispa, Montreal, QC, Canada; 2Department of Plastic Surgery, Université de Montreal, Montreal, QC, Canada; 3VP Research Unit, Montreal, QC, Canada; 4Erevna Innovations Inc., Montreal, QC, Canada; 5Department of Experimental Surgery, McGill University, Montreal, QC, Canada

Background: Loss of the viscoelastic properties of the skin is a primary sign of aging and contributes to the appearance of wrinkles. Hyaluronic acid (HA) fillers are one of the most commonly used treatments for age-related soft-tissue reduction and volume loss. Evidence is also emerging that HA fillers rejuvenate the skin.
Methods: A retrospective chart review was completed on 20 subjects treated with small particle HA (SP-HA), to investigate its effects on skin properties. Subjects having received three treatments in the face, neck, and/or hands were considered in the analyses. Skin hydration, trans-epidermal water loss (TEWL), and pH were assessed at baseline (injection #1), Week 4 (injection #2), Week 8 (injection #3), and Week 12 (follow-up).
Results: Treatment with SP-HA significantly improved hydration levels in the face, neck, and hands. Significant results were seen in the face following the first three treatments, with subjects moving up to the next hydration level (ie, hydration went from dry to moisturized) and by the second treatment in the neck and hands. TEWL scores on the face and neck remained within healthy values throughout all visits. At baseline, TEWL scores on the hands were within critical condition and after three injections they recuperated to healthy values, while pH values remained within the normal range throughout treatment.
Conclusion: A treatment regimen consisting of three SP-HA injections was safe and well tolerated. SP-HA use demonstrated a hydrating effect while positively impacting the skin’s ability to retain moisture.

Keywords: restylane, skinboosters, hyaluronic-acid, HA, skin, hydration

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