Back to Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Engineered nanomaterial uptake and tissue distribution: from cell to organism

Authors Kettiger H, Schipanski A, Wick P, Huwyler J

Received 12 June 2013

Accepted for publication 20 July 2013

Published 27 August 2013 Volume 2013:8(1) Pages 3255—3269


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Helene Kettiger,1,* Angela Schipanski,2,* Peter Wick,2 Jörg Huwyler1

1Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Basel, Switzerland; 2Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Materials-Biology Interactions, St Gallen, Switzerland

*These authors contributed equally to this work

Abstract: Improved understanding of interactions between nanoparticles and biological systems is needed to develop safety standards and to design new generations of nanomaterials. This article reviews the molecular mechanisms of cellular uptake of engineered nanoparticles, their intracellular fate, and their distribution within an organism. We have reviewed the available literature on the uptake and disposition of engineered nanoparticles. Special emphasis was placed on the analysis of experimental systems and their limitations with respect to their usefulness to predict the in vivo situation. The available literature confirms the need to study particle characteristics in an environment that simulates the situation encountered in biological systems. Phenomena such as protein binding and opsonization are of prime importance since they may have a strong impact on cellular internalization, biodistribution, and immunogenicity of nanoparticles in vitro and in vivo. Extrapolation from in vitro results to the in vivo situation in the whole organism remains a challenge. However, improved understanding of physicochemical properties of engineered nanoparticles and their influence on biological systems facilitates the design of nanomaterials that are safe, well tolerated, and suitable for diagnostic or therapeutic use in humans.

Keywords: biodistribution, cellular transport, cellular uptake, endocytosis, engineered nanomaterials, nanosafety

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other article by this author:

Polymersomes containing quantum dots for cellular imaging

Camblin M, Detampel P, Kettiger H, Wu D, Balasubramanian V, Huwyler J

International Journal of Nanomedicine 2014, 9:2287-2298

Published Date: 12 May 2014

Readers of this article also read:

Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin): comparison of treatment efficacy and distribution characteristics in vivo

Reshetov V, Lassalle HP, François A, Dumas D, Hupont S, Gräfe S, Filipe V, Jiskoot W, Guillemin F, Zorin V, Bezdetnaya L

International Journal of Nanomedicine 2013, 8:3817-3831

Published Date: 8 October 2013

Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant

Dupeyrón D, Kawakami M, Ferreira AM, Cáceres-Vélez PR, Rieumont J, Azevedo RB, Carvalho JCT

International Journal of Nanomedicine 2013, 8:3467-3477

Published Date: 13 September 2013

Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat

Barrefelt A, Saghafian M, Kuiper R, Ye F, Egri G, Klickermann M, Brismar TB, Aspelin P, Muhammed M, Dähne L, Hassan M

International Journal of Nanomedicine 2013, 8:3241-3254

Published Date: 26 August 2013

Intravenous magnetic nanoparticle cancer hyperthermia

Huang HS, Hainfeld JF

International Journal of Nanomedicine 2013, 8:2521-2532

Published Date: 17 July 2013

Enhanced bactericidal potency of nanoliposomes by modification of the fusion activity between liposomes and bacterium

Ma YF, Wang Z, Zhao W, Lu TL, Wang RT, Mei QB, Chen T

International Journal of Nanomedicine 2013, 8:2351-2360

Published Date: 28 June 2013

Preparation, characterization, and in vivo evaluation of tanshinone IIA solid dispersions with silica nanoparticles

Jiang YR, Zhang ZH, Liu QY, Hu SY, Chen XY, Jia XB

International Journal of Nanomedicine 2013, 8:2285-2293

Published Date: 25 June 2013

Development of biodegradable methylprednisolone microparticles for treatment of articular pathology using a spray-drying technique

Tobar-Grande B, Godoy R, Bustos P, von Plessing C, Fattal E, Tsapis N, Olave C, Gómez-Gaete C

International Journal of Nanomedicine 2013, 8:2065-2076

Published Date: 27 May 2013

Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic, for topical skin therapy

Li C, Zhang X, Huang X, Wang X, Liao G, Chen Z

International Journal of Nanomedicine 2013, 8:1285-1292

Published Date: 24 March 2013