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Effects of Cyclopentolate Hydrochloride Dosage on Anterior Segment Parameters in Young Adults (Measured with Pentacam)

Authors Alghamdi WM, Alrasheed SH, Nair V, Alluwimi MS

Received 15 November 2020

Accepted for publication 28 January 2021

Published 1 March 2021 Volume 2021:15 Pages 891—898

DOI https://doi.org/10.2147/OPTH.S291991

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Waleed M Alghamdi, Saif H Alrasheed, Vishakh Nair, Muhammed S Alluwimi

Department of Optometry, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia

Correspondence: Saif H Alrasheed
Qassim Unversity, P.O. Box 1162, Buraydah, Saudi Arabia
Tel +966505201475
Fax +966-16-3800050
Email [email protected]

Purpose: To assess the effects of 0.5% and 1% cyclopentolate on the main parameters of the anterior segment (central corneal thickness (CCT), anterior chamber angle (ACA), depth (ACD) and volume (ACV)) in low/moderate myopia and hyperopia along with the effect on IOP.
Patients and Methods: Both eyes of 30 subjects (15 myopic and 15 hyperopic) with mean age±standard deviation of 21.4± 3.6 years were enrolled. Each participant was administered two drops of cyclopentolate 1% in the right eye and two drops of cyclopentolate 0.5% in the left eye, 15 minutes apart. All participants underwent intraocular pressure (IOP) measurement using noncontact tonometry, and anterior chamber parameter measurement using Pentacam.
Results: Following the use of 0.5% and 1% cyclopentolate among the hyperopic group, there was a statistically significant increase in ACD for 1% (pre 2.762± 0.28 mm and post 2.89± 0.25 mm) and 0.5% (pre 2.71± 0.28 and post 2.86± 0.27 mm) and ACV for 1% (pre 141.40± 20.59 mm3 and post 154.35± 19.69 mm3) and 0.5% (pre 137.40± 20.48 mm3 and post 152.93± 20.50 mm3). In contrast, ACA decreased with both doses 1% and 0.5%, but was not statistically significant (p for both > 0.05%). With 0.5% and 1% cyclopentolate among the myopia group, there was a significant increase in ACD following cyclopentolate 1% (pre 3.18± 0.22 mm and post 3.25± 0.21 mm) and 0.5% (pre 3.200± 0.22 mm and post 3.26± 0.05 mm), p˂0.05. The ACV was significantly increased following 1% cyclopentolate, p˂0.001. The ACA showed a statistically significant decrease following cyclopentolate 1%, P=0.01, but not a significant decrease after cyclopentolate 0.5%, P=0.170. There was a significant increase in the IOP after 1%, p˂0.001, while a decrease with 0.5%, p=0.008.
Conclusion: A topical dosage of cyclopentolate 1% showed significant changes in ACA and ACV among the hyperopia and myopic groups compared to 0.5%. Therefore, it is important to consider the use of a 0.5% cyclopentolate dosage to minimize changes to anterior chamber parameters.

Keywords: cycloplegic, anterior chamber angle, anterior chamber volume depth, central corneal thickness

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