Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study
On behalf of the Dry Eye Clinical Study Group (DECSG)
Ophthalmology Department, Fundación Jiménez Díaz, Madrid, Spain
Background: We assessed the effectiveness and tolerability of a dietary supplement based on the combination of omega-3 essential fatty acids and antioxidants on dry eye-related symptoms.
Methods: A total of 905 patients (72% women, median age 60 years) with dry eye syndrome and using artificial tears to relieve symptoms participated in an open-label prospective intervention study. They were recruited during a routine ophthalmological appointment. Patients were instructed to take three capsules/day of the nutraceutical formulation (Brudysec® 1.5 g) for 12 weeks. Dry eye symptoms (categorized as 0, none; 1, mild; 2, moderate; and 3, severe) included scratchy and stinging sensation in the eyes, eye redness, grittiness, painful eyes, tired eyes, grating sensation, and blurry vision.
Results: The mean intensity of dry eye symptoms varied from 1.1 (± standard deviation [SD] 0.9) for painful eyes to 2.0 (0.9) for grittiness, with a mean value of 11.9 (4.8) for all symptoms together. At week 12, all individual symptoms improved significantly (P<0.001). The mean value for all symptoms together decreased from a mean value of 11.9 (± SD 4.8) at baseline to 6.8 (± SD 4.5) after 12 weeks of treatment (P<0.001). There was a decrease in the percentage of patients in which dry eye symptoms predominated nearly all the time (53.5% versus 34.1%). A total of 68.1% of patients reported better tolerance to contact lenses after treatment. The mean number of daily instillations of artificial tears also decreased significantly (3.8 [± SD 1.6] versus 3.3 [± SD 1.6], P<0.001). A total of 634 patients (70.1%) did not report any adverse events. In the remaining patients with adverse events, the most frequent was fish-tasting regurgitation in 13.5% of cases, followed by nausea in 4.9%, diarrhea in 1.3%, and vomiting in 0.3%.
Conclusion: Dietary supplementation with a combination of omega-3 essential fatty acids and antioxidants was an effective treatment for dry eye.
Keywords: antioxidants, Brudysec 1.5 g, dry eye symptoms, nutraceutics, omega-3, polyunsaturated fatty acids
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]
Readers of this article also read:
Atiba A, Wasfy T, Abdo W, Ghoneim A, Kamal T, Shukry M
Published Date: 28 October 2015
Onishi SM, Asahi MG, Chou C, Gallemore RP
Published Date: 21 January 2015
Prospective, noncomparative, nonrandomized case study of short-term outcomes of 360° suture trabeculotomy ab interno in patients with open-angle glaucoma
Sato T, Hirata A, Mizoguchi T
Published Date: 5 January 2015
Pautler SE, Browning DJ
Published Date: 30 December 2014
Intracameral phenylephrine and ketorolac injection (OMS302) for maintenance of intraoperative pupil diameter and reduction of postoperative pain in intraocular lens replacement with phacoemulsification
Lindstrom RL, Loden JC, Walters TR, Dunn SH, Whitaker JS, Kim T, Demopulos GA, Tjia K
Published Date: 5 September 2014
Published Date: 28 August 2014
Published Date: 12 May 2014
Intraoperative endoscopic observation of sclerotomy site after cannula removal for 23-gauge vitrectomy
Hikichi T, Kitamei H, Kosaka S, Shioya S, Takami K
Published Date: 28 February 2014
Kim SJ, Cho YW, Seo SW, Kim SJ, Yoo JM
Published Date: 23 January 2014
Paschalis EI, Cade F, Melki S, Pasquale LR, Dohlman CH, Ciolino JB
Published Date: 7 January 2014