Effect of age, sex, and refractive errors on central corneal thickness measured by Oculus Pentacam®
Received 8 May 2017
Accepted for publication 8 June 2017
Published 30 June 2017 Volume 2017:11 Pages 1233—1238
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Nauman Hashmani,1 Sharif Hashmani,1 Azfar N Hanfi,1 Misbah Ayub,2 Choudhry M Saad,2 Hina Rajani,2 Marium G Muhammad,2 Misbahul Aziz1
1Department of Ophthalmology, Hashmanis Hospital, Karachi, Pakistan; 2Dow Medical College, Karachi, Pakistan
Background: Central corneal thickness (CCT) can be used to assess the corneal physiological condition as well as the pathological changes associated with ocular diseases. It has an influence on the measurement of intraocular pressure and is being used as a screening tool for refractive surgery candidates. The aim of this study was to determine the median CCT among normal Pakistani population and to correlate CCT with age, sex, and refractive errors.
Methods: We conducted a retrospective analysis of 5,171 healthy eyes in 2,598 patients who came to Hashmanis Hospital, Karachi, Pakistan. The age of the patients ranged from 6 to 70 years. The refractive error was gauged by an auto-refractometer, and CCT was measured using Oculus Pentacam®.
Results: The median CCT of our study was 541.0 µm with an interquartile range (IQR) of 44.0 µm. The median age was 26.0 years (IQR: 8.0). Median spherical equivalent (SE) of the patients was −4.3 D (IQR: 3.3) with the median sphere value as −4.0 D (IQR: 3.8). Lastly, the median cylinder was −1.0 D (IQR: 1.3). Age has a weak negative correlation with CCT (r=−0.058) and shows statistical significance (P<0.001). Additionally, males had thinner CCT readings than females (P=0.001). The cylinder values, on the other hand, had a significant (P=0.004) and positive correlation (r=0.154). Three values showed no significant correlation: sphere (P=0.100), SE (P=0.782), and the left or right eye (P=0.151).
Conclusion: Among the Pakistani population, CCT was significantly affected by three variables: sex, age, and cylinder. No relationship of CCT was observed with the left or right eye, sphere, and SE.
Keywords: refractive surgery, glaucoma, topography, sex, refractive errors, astigmatism
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