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Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment

Authors Park J, Kim SE, Kim EJ, Lee BI, Jeong JH, Na HR, Choi SH, Kang DY, Park KW

Received 3 January 2019

Accepted for publication 22 May 2019

Published 28 June 2019 Volume 2019:14 Pages 1167—1175


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Richard Walker

Jinse Park,1 Si-Eun Kim,1 Eun-Joo Kim,2 Byung In Lee,1 Jee Hyang Jeong,3 Hae Ri Na,4 Seong Hye Choi,5 Do-Young Kang,6 Kyung Won Park7

1Department of Neurology, Haueundae Paik Hospital, Inje University, Busan, South Korea; 2Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, South Korea; 3Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, South Korea; 4Department of Neurology, Bobath Memorial Hospital, Seongnam, South Korea; 5Department of Neurology, Inha University School of Medicine, Incheon, South Korea; 6Department of Nuclear Medicine, College of Medicine, Dong-A University, Busan, South Korea; 7Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine and Institute of Convergence Bio-Health, Busan, South Korea

Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI).
Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks.
Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed.
Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.

Keywords: mild cognitive impairment, cognitive training, brain PET

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