Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment
Received 3 January 2019
Accepted for publication 22 May 2019
Published 28 June 2019 Volume 2019:14 Pages 1167—1175
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 4
Editor who approved publication: Dr Richard Walker
Jinse Park,1 Si-Eun Kim,1 Eun-Joo Kim,2 Byung In Lee,1 Jee Hyang Jeong,3 Hae Ri Na,4 Seong Hye Choi,5 Do-Young Kang,6 Kyung Won Park7
1Department of Neurology, Haueundae Paik Hospital, Inje University, Busan, South Korea; 2Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, South Korea; 3Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, South Korea; 4Department of Neurology, Bobath Memorial Hospital, Seongnam, South Korea; 5Department of Neurology, Inha University School of Medicine, Incheon, South Korea; 6Department of Nuclear Medicine, College of Medicine, Dong-A University, Busan, South Korea; 7Department of Neurology, Cognitive Disorders and Dementia Center, Dong-A University College of Medicine and Institute of Convergence Bio-Health, Busan, South Korea
Purpose: We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI).
Patients and methods: Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks.
Results: The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed.
Conclusion: The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.
Keywords: mild cognitive impairment, cognitive training, brain PET
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