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Drug-related problems in patients with rheumatoid arthritis

Authors Ma SN, Zaman Huri H, Yahya F

Received 16 November 2018

Accepted for publication 1 February 2019

Published 21 March 2019 Volume 2019:15 Pages 505—524

DOI https://doi.org/10.2147/TCRM.S194921

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


Shu Ning Ma,1 Hasniza Zaman Huri,1,2 Fariz Yahya3

1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Clinical Investigation Centre, University of Malaya Medical Centre, Kuala Lumpur, Malaysia; 3Division of Rheumatology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

Background: Rheumatoid arthritis (RA) patients are at risk of acquiring drug-related problems (DRPs). However, there has been a lack of studies on DRPs in patients with RA up to now.
Method: This retrospective study was conducted in a tertiary hospital in Malaysia from January 2012 to December 2017 with the purpose of assessing DRPs in RA patients and factors associated with its occurrence. A total of 200 patients who had received pharmacological treatment for RA were enrolled in this study. Assessment of DRPs was based on the Pharmaceutical Network Care Europe tool version 5.01.
Results: A total of 289 DRPs with an average of 1.5±1.0 problems per patient were identified, in which 78.5% of the population had at least one DRP. The most common DRPs encountered were adverse reactions (38.8%), drug interactions (33.6%), and drug-choice problems (14.5%). Factors that had significant association with the occurrence of DRPs were polypharmacy (P=0.003), multiple comorbidities (P=0.001), hyperlipidemia (P=0.009), osteo (P=0.040), and renal impairment (P=0.044). These data indicated that the prevalence of DRPs was high among RA patients.
Conclusion: Early identification of types of DRPs and associated factors may enhance the prevention and management of RA.

Keywords: RA drugs, DRPs, factor associated, prevention and management


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