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Cysteamine hydrochloride eye drop solution for the treatment of corneal cystine crystal deposits in patients with cystinosis: an evidence-based review

Authors Makuloluwa AK, Shams F

Received 8 August 2017

Accepted for publication 15 November 2017

Published 24 January 2018 Volume 2018:12 Pages 227—236

DOI https://doi.org/10.2147/OPTH.S133516

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Achini K Makuloluwa, Fatemeh Shams

Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK

Abstract: Cystinosis is a rare, autosomal recessive disorder leading to defective transport of cystine out of lysosomes. Subsequent cystine crystal accumulation can occur in various tissues, including the ocular surface. This review explores the efficacy of cysteamine hydrochloride eye drops in the treatment of corneal cystine crystal accumulation and its safety profile.

Keywords: cysteine, CTNS gene, cystaran, cystadrops

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