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Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis

Authors Mederle OA, Balas M, Ioanoviciu SD, Gurban CV, Tudor A, Borza C

Received 4 April 2018

Accepted for publication 11 May 2018

Published 3 August 2018 Volume 2018:13 Pages 1383—1389

DOI https://doi.org/10.2147/CIA.S170111

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Ovidiu Alexandru Mederle,1,* Melania Balas,2,* Sorin Dumitru Ioanoviciu,3,* Camelia-Vidita Gurban,4 Anca Tudor,5 Claudia Borza6

1Department of Microscopic Morphology/Histology, Angiogenesis Research Center, 2Department of Endocrinology, 3Department of First Internal Medicine, 4Department of Biochemistry and Pharmacology, 5Department of Informatics and Medical Biostatistics, 6Department of Pathophysiology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania

*These authors contributed equally to this work

Introduction: Bone mass density (BMD) is still the gold standard for the diagnosis of osteoporosis, but bone turnover markers (BTMs) can provide helpful information regarding the bone remodeling process. The aim of this study was to determine the correlations between BMD and serum levels of BTMs (tartrate-resistant acid phosphatase-5b [TRAP-5b]), bone-specific alkaline phosphatase (BSAP), estradiol (E2), and magnesium (Mg[2+]) ion concentrations in postmenopausal osteoporotic women as compared to healthy postmenopausal subjects.
Materials and methods: The study included 132 women with postmenopausal osteoporosis and 81 healthy postmenopausal women without osteoporosis. Dual-energy X-ray absorptiometry scan assessed BMD at different skeleton sites. Serum levels of E2, BSAP, and TRAP-5b were measured by enzyme linked immunosorbent assay. Serum levels of Mg(2+) were determined using the colorimetric spectrometry technique.
Results: Serum levels of BTMs were significantly higher in osteoporotic women than in controls. BSAP has a moderate sensitivity (76.5%) and specificity (84.3%) (cutoff point 21.27 U/L). At a cutoff point of 3.45 U/L, TRAP-5b presented a sensitivity of 86.3% and a higher specificity of 90.6%. Osteoporotic patients showed significantly lower concentrations of serum Mg(2+) than the control group. Mg(2+) levels correlated positively with BMD values (r=0.747, P<0.0001). Furthermore, Mg(2+) concentrations correlated positively with E2 levels (r=0.684, P<0.0001). Spine BMD correlated negatively with BSAP levels (r=-0.36, P<0.0001).
Conclusion: Our study showed that BMD correlates negatively with BTMs and positively with E2 and Mg(2+) levels. TRAP-5b presents a good specificity in identifying patients with postmenopausal osteoporosis.

Keywords:
bone mass density, tartrate-resistant acid phosphatase-5b, bone-specific alkaline phosphatase

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