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Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes

Authors Kohmoto R, Sugiyama T, Ueki M, Kojima S, Maeda M, Nemoto E, Tokuoka S, Ikeda T

Received 22 April 2019

Accepted for publication 13 August 2019

Published 12 September 2019 Volume 2019:13 Pages 1799—1805

DOI https://doi.org/10.2147/OPTH.S213031

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Ryohsuke Kohmoto,1 Tetsuya Sugiyama,1 Mari Ueki,1,2 Shota Kojima,1 Michiko Maeda,1 Emika Nemoto,1 Satoru Tokuoka,3 Tsunehiko Ikeda1

1Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan; 2Department of Ophthalmology, Takatsuki Red Cross Hospital, Takatsuki, Japan; 3Department of Ophthalmology, Hokusetsu General Hospital, Takatsuki, Japan

Correspondence: Ryohsuke Kohmoto
Department of Ophthalmology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan
Tel +81 72 683 1221
Fax +81 72 681 8195
Email ryousuke0218@hotmail.co.jp

Purpose: To investigate the relationship between laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA) measurements of the peripapillary retina and optic nerve head (ONH) in normal eyes and eyes with primary open-angle glaucoma (POAG).
Patients and methods: One eye from each of 46 normal subjects and mild and moderate/advanced POAG patients were included. ONH blood flow acquired by LSFG, circumpapillary vessel density (cpVD, a 250 μm-wide elliptical annulus around the optic disc), and intra-papillary vessel density (ipVD, a 1.5×1.5 mm scan field) acquired by OCTA were measured. Their values were compared among normal controls and patients at each stage of glaucoma using one-way ANOVA, and the correlation between measurements obtained by the two methods was examined by univariate regression analysis.
Results: ONH tissue blood flow, tissue mean blur rate (MBR-T), and cpVD in the outer layer of the retina significantly decreased with the progression of glaucoma stage, although the latter showed no significant difference between normal subjects and mild-stage glaucoma patients. MBR-T was significantly correlated with cpVD, but not with ipVD, in the retinal outer layer.
Conclusion: A correlation was found only between MBR-T and cpVD in the retinal outer layer. A difference in MBR-T, but not in cpVD, was detected between normal controls and mild glaucoma patients.

Keywords: optic nerve head, blood flow, laser speckle flowgraphy, optical coherent tomography angiography


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