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Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields

Authors Blümler P, Friedrich RP, Pereira J, Baun O, Alexiou C, Mailänder V

Received 19 December 2020

Accepted for publication 20 February 2021

Published 6 April 2021 Volume 2021:14 Pages 91—100

DOI https://doi.org/10.2147/NSA.S298003

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Professor Israel (Rudi) Rubinstein


Supplementary video 1 of "Contactless nanoparticle-based guiding of cells" [ID 298003].

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Peter Blümler,1 Ralf P Friedrich,2 Jorge Pereira,3 Olga Baun,1 Christoph Alexiou,2 Volker Mailänder3,4

1Institute of Physics, Johannes Gutenberg-University Mainz, Mainz, 55128, Germany; 2Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Erlangen, 91054, Germany; 3Department of Physical Chemistry, Max Planck Institute for Polymer Research, Mainz, 55128, Germany; 4Department of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, 55131, Germany

Correspondence: Peter Blümler
Institute of Physics, Johannes Gutenberg-University Mainz, Staudingerweg 7, Mainz, 55128, Germany
Tel +49 6131 3924240
Fax +49 6131 3925179
Email [email protected]

Abstract: Controlled and contactless movements of magnetic nanoparticles are crucial for fundamental biotechnological and clinical research (eg, cell manipulation and sorting, hyperthermia, and magnetic drug targeting). However, the key technological question, how to generate suitable magnetic fields on various length scales (μm–m), is still unsolved. Here, we present a system of permanent magnets which allows for steering of iron oxide nanoparticles (SPIONs) on arbitrary trajectories observable by microscopy. The movement of the particles is simply controlled by an almost force-free rotation of cylindrical arrangements of permanent magnets. The same instrument can be used to move suspended cells loaded with SPIONs along with predetermined directions. Surprisingly, it also allows for controlled movements of intracellular compartments inside of individual cells. The exclusive use of permanent magnets simplifies scaled up versions for animals or even humans, which would open the door for remotely controlled in vivo guidance of nanoparticles or micro-robots.

Keywords: permanent magnets, Halbach, super-paramagnetic, steering, targeting

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