Back to Journals » Clinical Ophthalmology » Volume 11

Comparison of intraocular pressure fluctuations before and after ab interno trabeculectomy in pseudoexfoliation glaucoma patients

Authors Tojo N, Abe S, Miyakoshi M, Hayashi A

Received 1 June 2017

Accepted for publication 22 August 2017

Published 14 September 2017 Volume 2017:11 Pages 1667—1675

DOI https://doi.org/10.2147/OPTH.S143061

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Naoki Tojo, Shinya Abe, Mari Miyakoshi, Atsushi Hayashi

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

Purpose: Ab interno trabeculectomy (AIT) with the Trabectome has been shown to reduce intraocular pressure (IOP) in eyes with pseudoexfoliation (PEX) glaucoma. Here, we examined the change of IOP fluctuations before and after only AIT or AIT with cataract surgery in PEX patients using the contact lens sensor Triggerfish®.
Methods: This was a prospective open-label study. Twenty-four consecutive patients with PEX glaucoma were included. Twelve patients underwent cataract surgery and AIT (triple-surgery group), and 12 patients underwent only AIT (single-surgery group). In each eye, IOP fluctuations over 24 h were measured with the contact lens sensor before and at 3 months after the surgery. We compared the change of IOP fluctuation before and after operation. We also evaluated the difference in IOP changes between the triple- and single-surgery groups.
Results: At 3 months after the surgeries, the mean IOP was significantly reduced from 23.5±6.5 mmHg to 14.6±2.8 mmHg in the single-surgery group and from 22.5±3.0 mmHg to 11.5±2.9 mmHg in the triple-surgery group. The mean IOP reduction rate was significantly higher in the triple-surgery group compared to the single-surgery group (p=0.0358). In both groups, the mean range of IOP fluctuations was significantly decreased during nocturnal periods. The mean range of 24 h IOP fluctuations was decreased in the triple-surgery group (p=0.00425), not in the single-surgery group (p=0.970).
Conclusion: Triple surgery could decrease IOP value and the IOP fluctuations to a greater extent than single surgery in PEX glaucoma patients.

Keywords: pseudoexfoliation, ab interno trabeculectomy, contact lens sensor, fluctuation, intraocular pressure

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Correlation between short-term and long-term intraocular pressure fluctuation in glaucoma patients

Tojo N, Abe S, Miyakoshi M, Hayashi A

Clinical Ophthalmology 2016, 10:1713-1717

Published Date: 2 September 2016

Corneal decompensation following filtering surgery with the Ex-PRESS® mini glaucoma shunt device

Tojo N, Hayashi A, Miyakoshi A

Clinical Ophthalmology 2015, 9:499-502

Published Date: 17 March 2015

Analysis of macular cone photoreceptors in a case of occult macular dystrophy

Tojo N, Nakamura T, Ozaki H, Oka M, Oiwake T, Hayashi A

Clinical Ophthalmology 2013, 7:859-864

Published Date: 8 May 2013

Adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa

Tojo N, Nakamura T, Fuchizawa C, Oiwake T, Hayashi A

Clinical Ophthalmology 2013, 7:203-210

Published Date: 23 January 2013

Near-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 1

Ueda-Consolvo T, Miyakoshi A, Ozaki H, Houki S, Hayashi A

Clinical Ophthalmology 2012, 6:1191-1194

Published Date: 27 July 2012