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Comparison of anterior chamber flare among different glaucoma surgeries

Authors Tanito M, Manabe K, Mochiji M, Takai Y, Matsuoka Y

Received 17 June 2019

Accepted for publication 13 August 2019

Published 22 August 2019 Volume 2019:13 Pages 1609—1612

DOI https://doi.org/10.2147/OPTH.S219715

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Masaki Tanito,1,2 Kaoru Manabe,1 Mihoko Mochiji,1 Yasuyuki Takai,1 Yotaro Matsuoka2

1Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Japan; 2Division of Ophthalmology, Matsue Red Cross Hospital, Matsue, Japan

Correspondence: Masaki Tanito
Department of Ophthalmology, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
Tel +81 85 320 2284
Fax +81 85 320 2278
Email tanito-oph@umin.ac.jp

Purpose: To compare postsurgical anterior chamber flare (ACF) among conventional (trabeculectomy, LEC) and novel (EX-PRESS Shunt, EXP) filtration surgeries and microhook ab interno trabeculotomy (μLOT), a novel minimally invasive glaucoma surgery (MIGS).
Subjects and methods: This retrospective study included 125 primary open angle glaucoma eyes (89 consecutive subjects) treated with μLOT (n=38), LEC (n=12), or EXP (n=75). The intraocular pressure (IOP), numbers of antiglaucoma medication, and ACF at preoperatively and 2 weeks; 1, 3, and 6 months postoperatively were compared among the surgical groups using a mixed-effects regression model.
Results: The postoperative IOP (p<0.0001) and medication use were significantly (p<0.0001) lower in the LEC and EXP groups than with μLOT for up to 6 months postoperatively. The ACF differed significantly (p=0.0004) among groups; the ACF was significantly higher (p=0.0097, post-hoc Student’s t-test) with μLOT (33.6±52.8 pc/msec) than the EXP (15.7±19.9 pc/msec) at 2 weeks and was significantly (p=0.0111, post-hoc t-test) lower with μLOT (7.9±2.0 pc/msec) than LEC (12.0±6.1 pc/msec) at 6 months.
Conclusion: Considering our observation, although its clinical significance is unclear, not all MIGS are minimally invasive regarding early postsurgical inflammation.

Keywords: anterior chamber flare, trabeculectomy, EX-PRESS shunt, microhook ab interno trabeculotomy, minimally invasive glaucoma surgery, MIGS

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