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Comparing Combination Drop Therapy to a Standard Drop Regimen After Routine Cataract Surgery

Authors Solomon KD, Sandoval HP, Potvin R

Received 2 May 2020

Accepted for publication 1 July 2020

Published 10 July 2020 Volume 2020:14 Pages 1959—1965


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Kerry D Solomon,1 Helga P Sandoval,1 Richard Potvin2

1Carolina Eyecare Physicians, Mt Pleasant, SC, USA; 2Science in Vision, Bend, OR, USA

Correspondence: Kerry D Solomon
Carolina Eyecare Physicians, LLC, 1101 Clarity Road, Suite 100, Mt Pleasant, SC 29464, USA

Purpose: To evaluate the efficacy of a combined steroid/antibiotic/non-steroidal anti-inflammatory drop relative to a regimen of multiple drops after cataract surgery.
Setting: Single clinical practice in the USA.
Design: Prospective randomized contralateral eye study.
Methods: Subjects presenting for bilateral cataract surgery were enrolled with contralateral eyes randomly assigned to one of the two groups. Test eyes received a combination therapy (prednisolone acetate 1%, gatifloxacin 0.5%, and bromfenac sodium 0.075%) while control eyes received the same medications in separate drops (bromfenac sodium was 0.07%). Subjects were examined 1, 15 and 30 days after surgery. Visual acuities were measured, along with the refraction, intraocular pressure, patient pain and satisfaction, macular thickness and corneal pachymetry. The primary measure of interest was the change in macular thickness from baseline to the 15- and 30-day visits. The frequency and severity of reported ocular adverse events were tabulated for each group and compared.
Results: Thirty-three subjects completed the study. Changes in central macular thickness were similar between groups, with only one control eye exhibiting significant macular edema. No differences in visual acuity, corneal edema, cells or flare were observed between groups. There were eight mild adverse events reported for all eyes of all subjects; the difference in the number of eyes experiencing adverse events was not statistically significantly different between groups (p ≥ 0.05 for all comparisons). While subjective symptoms were similar, all subjects indicated that they preferred the combination drop.
Conclusion: A combination drop showed similar efficacy to multiple drops and was overwhelmingly preferred by subjects.

Keywords: bromfenac sodium, gatifloxacin, prednisolone acetate, combination drop

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