Back to Journals » Pharmacogenomics and Personalized Medicine » Volume 9

Comments on Lucire and Crotty, 2011

Authors Loonen AJM, Verkes RJ

Received 29 April 2016

Accepted for publication 2 May 2016

Published 18 August 2016 Volume 2016:9 Pages 85—87

DOI https://doi.org/10.2147/PGPM.S111666

Checked for plagiarism Yes

Editor who approved publication: Dr Martin Bluth

Anton JM Loonen,1 Robbert-Jan Verkes2

1Pharmacotherapy of Psychiatric Patients, University of Groningen, Groningen, the Netherlands; 2Forensic Psychiatry, Radboud University, Nijmegen, the Netherlands


In a recent article, Yolande Lucire and Christopher Crotty presented their findings in an ongoing naturalistic study concerning a possible relationship between variant alleles in three CYP450 genes and a variety of behavioral problems.1 Unfortunately, the tested population of 129 persons was very heterogeneous and poorly characterized from a phenomenological perspective. In the results section of their article, the authors use the term “akathisia” to describe the adversity, but without defining this phenomenon. They also use this term in the title of their paper. Since they state that the majority of the persons who experienced adverse clinical events had akathisia, which is not expected considering their clinical characteristics, it is possible that the term has been used to describe other types of problems rather than this well-defined extrapyramidal motor disorder.2,3

View the original paper by Lucire and Crotty.


Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]