Back to Journals » Clinical Interventions in Aging » Volume 11

Colorectal cancer development and advances in screening

Authors Simon K

Received 26 March 2016

Accepted for publication 28 April 2016

Published 19 July 2016 Volume 2016:11 Pages 967—976

DOI https://doi.org/10.2147/CIA.S109285

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Supriya Swarnkar

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker

Karen Simon

Ventura County Gastroenterology Medical Group, Inc., Camarillo, CA, USA


Abstract: Most colon tumors develop via a multistep process involving a series of histological, morphological, and genetic changes that accumulate over time. This has allowed for screening and detection of early-stage precancerous polyps before they become cancerous in individuals at average risk for colorectal cancer (CRC), which may lead to substantial decreases in the incidence of CRC. Despite the known benefits of early screening, CRC remains the second leading cause of cancer-related deaths in the United States. Hence, it is important for health care providers to have an understanding of the risk factors for CRC and various stages of disease development in order to recommend appropriate screening strategies. This article provides an overview of the histological/molecular changes that characterize the development of CRC. It describes the available CRC screening methods and their advantages and limitations and highlights the stages of CRC development in which each screening method is most effective.

Keywords: colorectal cancer, DNA test, polyps, screening

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