Back to Journals » Integrated Blood Pressure Control » Volume 4

Clinical utility of fixed-combination telmisartan–amlodipine in the treatment of hypertension

Authors Segura J, Ruilope L

Published 19 May 2011 Volume 2011:4 Pages 27—34

DOI https://doi.org/10.2147/IBPC.S9934

Review by Single-blind

Peer reviewer comments 3

Julian Segura, Luis M Ruilope
Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain

Abstract: The majority of hypertensive patients, especially those with target organ damage, are likely to require multiple-drug therapy in order to reach blood pressure (BP) targets and reduce their risk of adverse vascular outcomes. The rationale for combination therapy with agents that block the renin–angiotensin system (RAS) and a calcium channel blocker (CCB) or diuretic is well founded in growing evidence. Recent published trials have shown that the combination of an RAS suppressor and a dihydropiridinic CCB would offer additional benefits independently of BP reduction. A telmisartan–amlodipine combination has demonstrated significantly greater BP reductions compared with each monotherapy component in the overall population, and in particular in patients with moderate to severe hypertension and high-risk patients. This combination is well tolerated with a safety profile similar to placebo and is consistent with the known safety profile of its monotherapy components.

Keywords: hypertensive patients, monotherapy, stroke, antihypertensive

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]