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Circadian rhythm and sleep influences on digestive physiology and disorders

Authors Vaughn B, Rotolo S, Roth H

Received 19 February 2014

Accepted for publication 27 May 2014

Published 2 September 2014 Volume 2014:4 Pages 67—77


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Bradley V Vaughn, Sean Rotolo, Heidi L Roth

Division of Sleep Medicine, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA

Abstract: Circadian rhythms and sleep influence a variety of physiological functions, including the digestive system. The digestive system also has intrinsic rhythms that interact dynamically with circadian rhythms. New advances in understanding the interaction of these rhythms and sleep provide the prospect of evaluating their role in normal physiology and the link of their disruption to pathological conditions. Recent work has demonstrated that sleep and circadian factors influence appetite, nutrient absorption, and metabolism. Disruption of sleep and circadian rhythms may increase vulnerability to digestive disorders, including reflux, ulcers, inflammatory bowel issues, irritable bowel disease, and gastrointestinal cancer. As our knowledge of the link between circadian timing and gastrointestinal physiology grows, so do our opportunities to provide promising diagnostic and therapeutic approaches for gastrointestinal disorders.

Keywords: digestion, digestive diseases, gastrointestinal reflux, sleep, circadian rhythm

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