Back to Journals » Research and Reports in Biochemistry » Volume 5

Cell–matrix interactions governing skin repair: matricellular proteins as diverse modulators of cell function

Authors Walker J, Kim S, Michelsons S, Creber K, Elliott C, Leask A, Hamilton D

Received 18 December 2014

Accepted for publication 7 January 2015

Published 5 March 2015 Volume 2015:5 Pages 73—88


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Nikolay Dokholyan

John T Walker,1,* Shawna S Kim,1,* Sarah Michelsons,1,* Kendal Creber,2,* Christopher G Elliott,1,* Andrew Leask,3 Douglas W Hamilton1–3

1Department of Anatomy and Cell Biology, 2Graduate Program of Biomedical Engineering, 3Division of Oral Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada
*These authors contributed equally to this paper

Abstract: With the classification first proposed by the Bornstein group in 1995, matricellular proteins represent a diverse and expanding class of molecules that contribute to cell phenotype and regulate interactions with the extracellular matrix. Based on initial analysis, matricellular protein expression was thought to be limited to development, but in the intervening 20 years it has become apparent that it plays a pivotal role during healing in several different tissue types. Furthermore, while considered to modulate cell behavior, it is now apparent that matricellular proteins also function in the organization and crosslinking of the extracellular matrix during healing. The focus of this review is to discuss matricellular proteins in the context of skin healing, which in healthy individuals occurs through four overlapping temporal phases. We will also discuss matricellular proteins as potential therapeutics for the treatment of impaired skin healing.

Keywords: matricellular proteins, skin healing, inflammation, cell adhesion, microenvironment

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

A new recombinant factor VIII: from genetics to clinical use

Santagostino E

Drug Design, Development and Therapy 2014, 8:2507-2515

Published Date: 12 December 2014

Second case report of successful electroconvulsive therapy for a patient with schizophrenia and severe hemophilia A

Saito N, Shioda K, Nisijima K, Kobayashi T, Kato S

Neuropsychiatric Disease and Treatment 2014, 10:865-867

Published Date: 16 May 2014

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Rituximab for managing acquired hemophilia A in a case of chronic neutrophilic leukemia with the JAK2 kinase V617F mutation

Imashuku S, Kudo N, Kubo K, Saigo K, Okuno N, Tohyama K

Journal of Blood Medicine 2012, 3:157-161

Published Date: 5 December 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010