Back to Journals » International Journal of Nanomedicine » Volume 7

Blood–brain barrier: a real obstacle for therapeutics

Authors Shiekh F

Received 12 May 2012

Accepted for publication 17 May 2012

Published 27 July 2012 Volume 2012:7 Pages 4065—4067


Farooq A Shiekh

Aix-Marseille Université, URMITE, UMR, CNRS 7278, IRD 198, Marseille, France

In a recent report published in the International Journal of Nanomedicine, Gulati et al1 have described the most innovative study addressing an important issue of the "blood–brain barrier," which can act as a barrier to one of the fundamental goals of modern neurobiology that would have a direct impact on highly debated future therapeutics for both brain cancer and neurological disorders. Contrary to what has been the case with conventional therapy, the authors were able to completely bypass the blood–brain barrier (Figure 1) – a limiting factor for efficient drug delivery – by proposing a new, alternative approach using nanoengineered TNT/Ti implants for local delivery of chemotherapeutics such as doxorubicin into the brain. There must be millions of good drugs sitting in pharmaceutical company stores that cannot be delivered simply because they cannot get past the blood–brain barrier.2 This is an area that has been under-researched and its significance has not yet been recognized. Neuroscience textbooks bury this issue in the appendix, PhD programs give it a cursory treatment, and pharmaceutical companies have tried to ignore it. Despite the blood–brain barrier acting as a stubbornly real obstacle for potential drugs to be used against many disorders of the central nervous system, the field of drug delivery is advancing rapidly.

View original paper by Gulati and colleagues.

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Editor’s choice: recent research highlights from the International Journal of Nanomedicine

Shiekh FA, Abu-Izzah AM, Lee VJ, Mudassar S

International Journal of Nanomedicine 2017, 12:4505-4508

Published Date: 19 June 2017

Research highlights from the International Journal of Nanomedicine 2014

Mian SH, Patel NA, Shah F, Arja SB, Shiekh FA

International Journal of Nanomedicine 2015, 10:2503-2505

Published Date: 31 March 2015

Targeted nanotherapeutics in cancer

Shiekh FA

International Journal of Nanomedicine 2014, 9:1627-1628

Published Date: 26 March 2014

Are calcifying microvesicles another analogous substructure of calcifying nanoparticles?

Atughonu TC, Arja SB, Shiekh FA

International Journal of Nanomedicine 2013, 8:4673-4676

Published Date: 5 December 2013

Do calcifying nanoparticles really contain 16S rDNA?

Shiekh FA

International Journal of Nanomedicine 2012, 7:5051-5052

Published Date: 18 September 2012

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010