Back to Journals » Clinical Ophthalmology » Volume 12

Blood pressure, ocular perfusion pressure and open-angle glaucoma in patients with systemic hypertension

Authors Cantor E, Méndez F, Rivera C, Castillo A, Martínez-Blanco A

Received 27 February 2018

Accepted for publication 7 May 2018

Published 23 August 2018 Volume 2018:12 Pages 1511—1517


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Erika Cantor,1 Fabián Méndez,2 Carlos Rivera,3 Andrés Castillo,4 Alexander Martínez-Blanco5

1Research Institute, Centro Médico Imbanaco, Cali, Colombia; 2School of Public Health, GESP Group, Universidad del Valle, Cali, Colombia; 3Centro Medico Farallones, Fundación Oftalmológica del Valle, Cali, Colombia; 4Department of Biology, Faculty of Natural and Exact Sciences, Universidad del Valle, Cali, Colombia; 5Department of Ophtalmology, Universidad del Valle, Research Institute, Centro Médico Imbanaco, Cali, Colombia

Background: The aim of the study was to evaluate the relationship between blood pressure (BP), ocular perfusion pressure (OPP) and occurrence of primary open-angle glaucoma (POAG) among patients with systemic hypertension.
Participants and methods: A cross-sectional study of hypertensive patients was conducted in six cities in Colombia. The participants underwent a complete ophthalmological examination. The intraocular pressure measurement was obtained by Goldmann tonometry. The diagnosis of glaucoma was confirmed by visual field and optic nerve photos. Interviews and questionnaires were used to evaluate participants’ lifestyle and other health conditions. A multinomial logistic regression was used to assess the relationship between BP, OPP and presence of suspected or confirmed POAG.
Results: A total of 1,272 individuals were included in this study; 131 (10.3%) were diagnosed with suspected glaucoma and 65 (5.1%) with confirmed glaucoma. High values of diastolic BP (>90 mmHg) and low values of OPP (<40 mmHg) were associated to an increased risk of confirmed POAG. The type of antihypertensive treatment did not modify these relationships.
Conclusion: This study suggests that there is a close relationship between OPP and confirmed glaucoma in hypertensive patients, providing further evidence of the vascular mechanism in glaucoma pathogenesis.

Keywords: open angle-glaucoma, blood pressure, ocular perfusion pressure, hypertension, ocular blood flow

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]