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Bilayered skin-substitute technology for the treatment of diabetic foot ulcers: current insights

Authors Karr JC

Received 28 August 2016

Accepted for publication 11 November 2016

Published 21 December 2016 Volume 2017:4 Pages 7—16

DOI https://doi.org/10.2147/CWCMR.S104052

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Marco Romanelli


Jeffrey C Karr

Karr Foot and Leg Center, Lakeland, FL, USA

Abstract: The estimated prevalence of diabetes mellitus in New Zealand is 7%, and as in many other developed countries is a growing problem. One of the most common and costly complications, diabetic foot ulcers (DFUs) are chronic wounds that result when the phases of wound healing are disrupted or incomplete, resulting in wounds that persist for several months or even years. Despite standard-care therapy (ie, debridement, infection elimination, use of dressings, off-loading), the majority of DFUs remain unhealed, and it is thus appropriate to consider advanced therapies. One such therapy is a bioengineered bilayered living cellular construct (BLCC) comprised of living keratinocytes and fibroblasts. BLCC facilitates the delivery of a broad array of cytokines and growth factors often deficient in chronic nonhealing wounds, and in doing so reverses patients’ wounds from a chronic wound to an acute normally healing wound. BLCC has an important body of evidence to support its use in DFUs, including randomized clinical trials, a real-world comparative-effectiveness analysis, and health-economics data.

Keywords: bilayer skin substitute, bilayered living cellular construct, chronic wounds, diabetic foot ulcers, wound healing

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