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Beneficial and deleterious bacterial–host interactions in chronic wound pathophysiology

Authors Watters C, Yuan T, Rumbaugh K

Received 23 December 2014

Accepted for publication 11 February 2015

Published 2 April 2015 Volume 2015:2 Pages 53—62

DOI https://doi.org/10.2147/CWCMR.S60317

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Marco Romanelli


Chase Watters,1 Tony T Yuan,1,2 Kendra P Rumbaugh3

1Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA; 2Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, TX, USA; 3Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, USA

Abstract: Chronic wounds represent a major health and financial burden. Although incredible advancements in wound management have been made in the last decade, the incidences of chronic wounds continue to increase due to a rise in biofilm-associated infections. The presence of biofilm causes chronic inflammation, leading to impaired healing rates and host mortality. This review describes the deleterious bacterial–host interactions, as well as the beneficial role of pH and probiotics in chronic wound infections.

Keywords: chronic wounds, biofilms, wound pH, Pseudomonas aeruginosa, Staphylococcus aureus, probiotics

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